Search results for "Atrial myocytes"
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Ranolazine-Mediated Attenuation of Mechanoelectric Feedback in Atrial Myocyte Monolayers.
2020
[EN] Background Mechanical stretch increases Na(+)inflow into myocytes, related to mechanisms including stretch-activated channels or Na+/H(+)exchanger activation, involving Ca(2+)increase that leads to changes in electrophysiological properties favoring arrhythmia induction. Ranolazine is an antianginal drug with confirmed beneficial effects against cardiac arrhythmias associated with the augmentation ofI(NaL)current and Ca(2+)overload. Objective This study investigates the effects of mechanical stretch on activation patterns in atrial cell monolayers and its pharmacological response to ranolazine. Methods Confluent HL-1 cells were cultured in silicone membrane plates and were stretched to…
Implication du récepteur 5-HT4 cardiaque humain dans la fibrillation auriculaire : rôle d’auto-anticorps dirigés contre ce récepteur ?
2004
The human cardiac 5-HT4 receptor was cloned in 1997. It is functional only in atrial myocytes where it is positively coupled via Gs to the adenylate cyclase, activates the cAMP-dependent protein kinase (PKA) and in consequence phosphorylates a variety of intracellular proteins implicated in excitation-contraction coupling. A number of studies suggest a role for the 5-HT4 receptor in the maintenance or elongation of atrial fibrillation. It is now accepted that certain cardiac pathologies involve auto-immune processes. Antibodies directed against the second extracellular loop of a number of cardiac G-protein linked receptors have been found. The human cardiac 5-HT4 receptor could therefore al…